| Date | Location | Result | |
| 03/16/22 | Gainesville, FL - Exactech Arena | Florida 79, Iona College 74 | Box score |
| 03/09/22 | Atlantic City, NJ - Boardwalk Hall | Rider 71, Iona College 70 | Box score |
| 03/05/22 | New Rochelle, NY - Hynes Center | Iona College 79, Quinnipiac 61 | Box score |
| 03/03/22 | Riverdale, NY - Draddy Gymasium | Manhattan 74, Iona College 72 | Box score |
| 02/27/22 | Lawrenceville, NJ - Alumni Gymnasium | Iona College 67, Rider 61 | Box score |
| 02/25/22 | New Rochelle, NY - Hynes Center | Iona College 72, Canisius 65 | Box score |
| 02/20/22 | New Rochelle, NY - Hynes Center | Iona College 76, Fairfield 58 | Box score |
| 02/15/22 | Jersey City, NJ - Run Baby Run Arena | Iona College 70, Saint Peter's 61 | Box score |
| 02/13/22 | New Rochelle, NY - Hynes Center | Iona College 70, Monmouth 62 | Box score |
| 02/11/22 | Albany, NY - MVP Arena | Siena 70, Iona College 64 | Box score |
| 02/06/22 | Lewiston, NY - Gallagher Center | Niagara 80, Iona College 71 | Box score |
| 02/04/22 | Buffalo, NY - Koessler Center | Iona College 70, Canisius 62 | Box score |
| 01/30/22 | New Rochelle, NY - Hynes Center | Iona College 85, Saint Peter's 77 | Box score |
| 01/25/22 | New Rochelle, NY - Hynes Center | Iona College 74, Siena 57 | Box score |
| 01/23/22 | Hamden, CT - People's United Center | Iona College 76, Quinnipiac 61 | Box score |
| 01/18/22 | West Long Branch, NJ - McNeil Arena | Iona College 86, Monmouth 85 (OT) | Box score |
| 01/16/22 | New Rochelle, NY - Hynes Center | Iona College 78, Niagara 55 | Box score |
| 01/14/22 | New Rochelle, NY - Hynes Center | Iona College 88, Manhattan 76 | Box score |
| 01/11/22 | Bridgeport, CT - Webster Bank Arena | Iona College 80, Fairfield 76 | Box score |
| 01/08/22 | St. Louis, MO - Chaifetz Arena | Saint Louis 68, Iona College 67 | Box score |
| 01/02/22 | New Rochelle, NY - Hynes Center | Iona College 69, Marist 66 | Box score |
| 12/21/21 | Belmont Park, NY - UBS Arena | Iona College 83, Delaware 72 | Box score |
| 12/12/21 | Brooklyn, NY - Barclays Center | Iona College 91, Yale 77 | Box score |
| 12/03/21 | New Rochelle, NY - Hynes Center | Iona College 80, Rider 54 | Box score |
| 12/01/21 | Poughkeepsie, NY - McCann Arena | Iona College 78, Marist 71 | Box score |
| 11/28/21 | Lake Buena Vista, FL - HP Field House | Kansas 96, Iona College 83 | Box score |
| 11/26/21 | Lake Buena Vista, FL - HP Field House | Belmont 72, Iona College 65 | Box score |
| 11/25/21 | Lake Buena Vista, FL - HP Field House | Iona College 72, Alabama 68 | Box score |
| 11/20/21 | Lake Buena Vista, FL - HP Field House | Iona College 81, North Alabama 65 | Box score |
| 11/19/21 | Lake Buena Vista, FL - HP Field House | Iona College 54, Liberty 50 | Box score |
| 11/16/21 | New Rochelle, NY - Hynes Center | Iona College 82, Hofstra 74 | Box score |
| 11/13/21 | New Rochelle, NY - Hynes Center | Iona College 90, Harvard 87 (OT) | Box score |
| 11/09/21 | New Rochelle, NY - Hynes Center | Iona College 65, Appalachian State 53 | Box score |